Directed ortho metalation - mediated F+ introduction. Regiospecific synthesis of fluorinated aromatics

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Abstract

Regiospecific fluorination using N-fluorobenzenesulfonimide (NFSi) and N-fluoro-O-benzenedisulfonimide (NFOBS) reagents via directed ortho metalation (Scheme 1) is reported and exceptions of PhSO2 transfer from NFSi are described. © 1994.

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Snieckus, V., Beaulieu, F., Mohri, K., Han, W., Murphy, C. K., & Davis, F. A. (1994). Directed ortho metalation - mediated F+ introduction. Regiospecific synthesis of fluorinated aromatics. Tetrahedron Letters, 35(21), 3465–3468. https://doi.org/10.1016/S0040-4039(00)73211-4

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