Metronidazole pessaries compared with placebo in the treatment of bacterial vaginosis

Abstract

In a randomized, double-blind clinical trial from general practice, 500 mg metronidazole pessaries applied once daily for seven days were compared with placebo in the treatment of bacterial vaginosis. Seventy-five women completed the study. At the follow-up visit immediately after completion of treatment, none of the patients on metronidazole fulfilled the criteria for bacterial vaginosis, compared with 12 (35% in the placebo group (p < 0.001). Nine (22% of the patients treated with metronidazole harboured Gardnerella vaginalis after treatments, compared with 31 (91% in the placebo group (p< 0.001). Symptoms had improved or disappeared in 33 (80% on metronidazole, and in 18 (53% on placebo therapy (p < 0.05). Four weeks after the follow-up visit, symptoms were reported by 28% in the metronidazole group and by 44% in the placebo group (p > 0.05). Metronidazole pessaries are effective in the treatment of bacterial vaginosis. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.