The Prader Willi syndrome with a 15/15 translocation. Case report and review of the literature

Abstract

A case, diagnosed clinically as the Prader Willi syndrome, was shown by Giemsa banding, to have a 15/15 chromosome translocation. A review of the literature indicates that such a translocation has only been described once before, in a normal woman, but that chromosome abnormalities in the Prader Willi syndrome most commonly involve the D group. The significance of this would be clarified by specific chromosome identification in these patients.