The combination of isomorphous replacement and anomalous scattering data in phase determination of non-centrosymmetric reflexions

Abstract

Earlier attempts to combine anomalous scattering data and isomorphous replacement data in phase determination are discussed. The relative weights given to the two types of observation have not been on a satisfactory basis; either an arbitrary method has been used or the intrinsic accuracy of the anomalous scattering data has not been realized. A new method is proposed, which allows appropriate weighting to be applied.