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Acute Plasmodium Infection Promotes Interferon-Gamma-Dependent Resistance to Ebola Virus Infection

Cell Reports (2020) 30(12) 4041-4051.e4
DOI: 10.1016/j.celrep.2020.02.104
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Abstract

Rogers et al. demonstrate that acute Plasmodium infection protects against lethal Ebola virus challenge. Protection is conferred by Plasmodium-elicited interferon gamma (IFN-γ) that causes M1 polarization of tissue macrophages. These studies provide insight into conflicting clinical data regarding whether malaria protects or sensitizes hosts to Ebola virus.

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Rogers, K. J., Shtanko, O., Vijay, R., Mallinger, L. N., Joyner, C. J., Galinski, M. R., … Maury, W. (2020). Acute Plasmodium Infection Promotes Interferon-Gamma-Dependent Resistance to Ebola Virus Infection. Cell Reports, 30(12), 4041-4051.e4. https://doi.org/10.1016/j.celrep.2020.02.104

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