Understanding uncertainty and ambiguity in medicine and medical education: a narrative review with implications for training

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Abstract

Medical students face significant challenges, including managing uncertainty, impacting their education and careers. Effective doctors prioritize patient care, competence, relationships, and integrity, yet students frequently struggle emotionally and idealistically, especially during preclinical years. Clinical rotations expose the inherent uncertainty in medicine, requiring students to develop contextual, sufficient knowledge. Uncertainty arises from knowledge gaps, complex systems, ambiguous scenarios, emotional challenges, negative role models, and unclear team roles, often causing psychological distress. Differentiating between ambiguity (unclear answers) and uncertainty (individual responses) is essential. Medical education should cultivate traits such as curiosity, courage, empathy, and tolerance for ambiguity, which can be fostered through medical humanities and simulation-based learning. Emphasizing reflection, peer support, and addressing the hidden curriculum are vital strategies. Enhancing professional development and mentorship tailored to students' needs can better equip future doctors, making embracing uncertainty integral to their professional growth and resilience in medical practice.

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APA

Sarkis, S., & Raphael, C. (2026). Understanding uncertainty and ambiguity in medicine and medical education: a narrative review with implications for training. Postgraduate Medical Journal, 102(1207), 461–465. https://doi.org/10.1093/postmj/qgaf170

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