Value of blood biomarkers in the diagnosis of Parkinson’s disease: a case-control study from Xinjiang

Abstract

Objective: Based on the data of Parkinson’s disease patients in Xinjiang, China, to explore the clinical application value of blood biomarkers in diagnosing Parkinson’s disease patients. Methods: The research subjects were patients with Parkinson’s disease who were diagnosed and hospitalized at the Second Affiliated Hospital of Xinjiang Medical University between January 2021 and January 2023 and those who underwent health check-ups at the hospital, 243 and 249 cases were included, respectively, and those who underwent health check-ups were used as a healthy control group of the Parkinson’s disease patient group. Results: Significant differences in age, systolic blood pressure, cystatin C, and uric acid distributions were found between healthy controls and Parkinson’s patients (P < 0.05), and multivariate analysis showed that there was a correlation between body mass index, uric acid, and Parkinson’s disease (P < 0.05), and that those who were overweight or obese, and those who had a low level of uric acid, had a greater probability of suffering from Parkinson’s disease (B > 0). There were significant differences in gender, cystatin C, and urea between Parkinson’s patients with a disease duration of < 5 years and those with a disease duration of ≥ 5 years (P < 0.05). In multivariate analysis, there was a correlation between gender and duration of Parkinson’s disease (P < 0.05), and the duration of the disease was greater in male patients than in females. Conclusion: Uric acid combined with body mass index is informative for early screening of Parkinson’s disease.