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Enhancing in vitro osteogenic differentiation of mesenchymal stem cells via sustained dexamethasone delivery in 3D-Printed hybrid scaffolds based on polycaprolactone-nanohydroxyapatite/alginate-gelatin for bone regeneration

Journal of Biological Engineering (2025) 19(1)
DOI: 10.1186/s13036-025-00514-y
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Abstract

Layer-by-layer 3D-printing was effectively applied to prepare a biomimetic combined structure composing hard composite (PCL-nHA) and soft hydrogel (Alg-Gel). 3D-printing scaffolds were used to control the delivery of dexamethasone (DEX) to enhance bone repair. DEX-loaded scaffolds promoted osteogenic differentiation and mineralization of human endometrial mesenchymal stem cells (hEnMSCs).

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Noory, P., Farmani, A. R., Ai, J., Bahrami, N., Bayat, M., Ebrahimi-Barough, S., … Goodarzi, A. (2025). Enhancing in vitro osteogenic differentiation of mesenchymal stem cells via sustained dexamethasone delivery in 3D-Printed hybrid scaffolds based on polycaprolactone-nanohydroxyapatite/alginate-gelatin for bone regeneration. Journal of Biological Engineering, 19(1). https://doi.org/10.1186/s13036-025-00514-y

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