Silica sulfuric acid as an efficient and reusable reagent for crossed-aldol condensation of ketones with aromatic aldehydes under solvent-free conditions

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Abstract

Aromatic aldehydes undergo crossed-aldol condensation with ketones in the presence of silica sulfuric acid under solvent-free conditions to afford the corresponding α,β-unsaturated aldol products in excellent yields. The reagent is reusable for several times without any decrease in the yield of the reactions.

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Salehi, P., Dabiri, M., Zolfigol, M. A., & Fard, M. A. B. (2004). Silica sulfuric acid as an efficient and reusable reagent for crossed-aldol condensation of ketones with aromatic aldehydes under solvent-free conditions. Journal of the Brazilian Chemical Society, 15(5), 773–776. https://doi.org/10.1590/S0103-50532004000500026

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