BACE1, the Alzheimer's beta-secretase enzyme, in health and disease

Abstract

Interestingly, impaired glucose metabolism occurs early in AD, and our work has demonstrated that glucose deprivation increases BACE1 levels and Abeta production in the brains of an APP transgenic model of AD, the Tg2576 mouse. Genetic and pharmacological manipulation of eIF2alpha phosphorylation was performed in vitro experiments. eIF2alpha S51A knock-in mice and GADD34-AAV injection into mouse brain was used for manipulation of eIF2alpha phosphorylation in vivo.