Binding of activated isoniazid with acetyl-CoA carboxylase from Mycobacterium tuberculosis

  • Unissa A
  • Sudha S
  • Selvakumar N
  • et al.
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Abstract

AccD6 (acetyl coenzyme A (CoA) carboxylase), plays an important role in mycolic acid synthesis of Mycobacterium tuberculosis (Mtb). Induced gene expression by isoniazid (isonicotinylhydrazine - INH), anti-tuberculosis drug) shows the expression of accD6. It is our interest to study the binding of activated INH with the AccD6 model using molecular docking procedures. The study predicts a primary binding site for activated INH (isonicotinyl acyl radical) in AccD6 as a potential target.

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Unissa, A. N., Sudha, S., Selvakumar, N., & Hassan, S. (2011). Binding of activated isoniazid with acetyl-CoA carboxylase from Mycobacterium tuberculosis. Bioinformation, 7(3), 107–111. https://doi.org/10.6026/97320630007107

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