Potential Activity of Serunai Leaf Ethanol Extract (Chromolaena Odorata L.) Against the Healing of Burns

Abstract

Burns is tissue damage caused by heat, excessive exposure to sunlight or other radiation, or chemical or electrical contact. Wounds are a problem that everyone often experiences, especially burns, so they need to be addressed. Empirically, the plant trusted by the community as a wound medicine is the serunai leaf. In South Sulawesi, serunai leaves are believed to heal wounds. This study aimed to determine whether there was an effect of healing burns on the backs of mice by administering ethanol extract of Serunai leaves (Chromolaena odorata L.). The research conducted is experimental. The object under study is the process of healing burns on the back of male white mice. The study was conducted on 25 male white mice aged 2-3 months with an average body weight of 20-40 grams, divided into five groups of test animals, each group consisting of 5 male white mice based on the Federer formula. The first group was given positive control (+) branded ointment, and the second group was given negative control (-) vaseline flavum, the third group was given ethanol extract of Serunai leaves with a concentration of 5%, the fourth group was given ethanol extract of Serunai leaves with a concentration of 10%. The fifth group was given ethanol extract of serunai leaves (the thick extract). Serunai leaves with a concentration of 20%, and each surface on the back of the mice was covered and calculated using AUC and analyzed by the One Way Anova test. The results showed that the ethanol extract of serunai leaves had the potential for healing burns. Each concentration has a burn healing power of 5% (48.76%), 10% (60.34%), and 20% (67.54%).