Hyaluronidase inhibitors as skin rejuvenating agents from natural source

Abstract

Introduction It is reported that the market of natural and organic products of personal care is ~11 billion US$ and expected to reach 22 billion US$ by 2022. 1 The market of cosmeceuticals from natural products is a demand nowadays to maintain a healthy skin instead of the use of harmful synthetic cosmetics. With age, the skin loses its original elasticity and suppleness due to enzyme elastase which leads to sagging, the collagen decreases and the dermis is replaced by abnormal elastic fibers. At the same time hyaluronic acid (HA) in the skin also diminishes and skin becomes dry and wrinkled. Degradation of extracellular matrix in epidermal and dermal layers occurs. Dermal components of the skin are degraded by the enzymes elastase, collagenase and hyaluronidase causing formation of wrinkles. Hence, there is a need to conserve matrix metallo-proteins by inhibiting the activity of these matrix metallo-proteinases. 2