Examining the efficacy of social-psychological interventions for the management of fatigue in end-stage kidney disease (ESKD): a systematic review with meta-analysis

Abstract

Fatigue affects between 42% and 89% of end-stage kidney disease (ESKD) patients, with significant repercussions on quality of life and clinical outcomes. Fatigue management revolves around pharmacotherapy or exercise, which have only modest and short-term improvements. The aim of this systematic review was to investigate whether social-psychological interventions are effective at reducing fatigue in ESKD. Databases were searched to identify randomized controlled trials (RCTs) and quasi-RCTs that determined the effect of social-psychological interventions on fatigue (primary or secondary outcome), in the renal patient population. A meta-analysis was conducted. Sixteen RCTs (N = 1536) were included, predominantly among dialysis patients. Fatigue was a primary outcome in only two studies. The meta-analytic findings showed a significant improvement in fatigue following social-psychological interventions (standardised mean difference, SMD = 0.37, p =.001; 95% CI 0.15 to 0.59, I² = 69.1%, p