Green syntheses of potentially bioactive α-hydroxyphosphonates and related derivatives

Abstract

α-Hydroxyphosphonates have been in the focus of interest for many years due to their potential in biological activity. Not only α-hydroxyphosphonates are of general importance, but also their derivatives. α-Aminophosphonates and α-hydroxyphosphonic acids have already been recognized for their biological effects, while phosphoryloxyphosphonates represent a new family of compounds. In this paper we present alternative syntheses towards α-hydroxyphosphonates and their derivatives.