The application of extended Modified Lambert Beer model for measurement of blood carboxyhemoglobin and oxyhemoglobin saturation

Abstract

This work presents the use of extended Modified Lambert Beer (MLB) model for accurate and continuous monitoring of percent blood carboxyhemoglobin (COHb) (SCO) and oxyhemoglobin (OxyHb) saturation (SO 2) via a fitting procedure. This quantification technique is based on the absorption characteristics of hemoglobin derivatives in the wavelength range of 520-600 nm to give the best estimates of the required parameters. A comparison of the performance of the developed model and MLB law is made using attenuation data from Monte Carlo simulations for a two-layered skin model. The results revealed a lower mean absolute error of 0.4% in the values estimated by the developed model as compared to 10% that is given by the MLB law. This study showed that the discussed approach is able to provide consistent and accurate measurement of blood SO 2 and SCO across different skin pigmentations suggesting that it may potentially be used as an alternative means for clinical diagnosis of carbon monoxide (CO) poisoning.