Synthetic Approach toward Enantiopure Cyclic Sulfinamides

Abstract

A synthetic approach toward densely substituted enantiopure cyclic sulfinamides possessing up to four consecutive stereogenic centers was developed based on a completely diastereoselective SN2′ cyclization/tert-Bu cleavage sequence. Diastereospecific transformation of the obtained scaffold into chiral SVIderivatives such as sulfoximines and sulfonimidamides is demonstrated. 2022 The Authors.