The inheritance of sickle-cell anemia upon the background of the major β-globin gene cluster haplotypes has been associated with differing risks for major organ failure, and more recently with response to hydroxyurea treatment. Early identification of β-globin haplotypes in individuals with sickle-cell anemia may be a clinically useful prognostic factor for severity of disease expression. This report describes the use of whole-blood spots on filter papers from newborn hemoglobinopathy screening for β-globin gene cluster haplotyping by the polymerase chain reaction.
CITATION STYLE
Hiti, A. L., Zeng, L., Xiang, Q., Lorey, F. W., & Powars, D. R. (1997). Beta-globin haplotypes from blood spots for follow-up of newborn hemoglobinopathy screening. American Journal of Hematology, 54(1), 76–78. https://doi.org/10.1002/(SICI)1096-8652(199701)54:1<76::AID-AJH12>3.0.CO;2-8
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