Beta-globin haplotypes from blood spots for follow-up of newborn hemoglobinopathy screening

4Citations
Citations of this article
16Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The inheritance of sickle-cell anemia upon the background of the major β-globin gene cluster haplotypes has been associated with differing risks for major organ failure, and more recently with response to hydroxyurea treatment. Early identification of β-globin haplotypes in individuals with sickle-cell anemia may be a clinically useful prognostic factor for severity of disease expression. This report describes the use of whole-blood spots on filter papers from newborn hemoglobinopathy screening for β-globin gene cluster haplotyping by the polymerase chain reaction.

Cite

CITATION STYLE

APA

Hiti, A. L., Zeng, L., Xiang, Q., Lorey, F. W., & Powars, D. R. (1997). Beta-globin haplotypes from blood spots for follow-up of newborn hemoglobinopathy screening. American Journal of Hematology, 54(1), 76–78. https://doi.org/10.1002/(SICI)1096-8652(199701)54:1<76::AID-AJH12>3.0.CO;2-8

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free