Increase in interleukin-6 immediately after wheelchair basketball games in persons with spinal cord injury: Preliminary report

Abstract

Study design:Case series.Objectives:To investigate the effects of wheelchair basketball game on plasma interleukin-6 (IL-6), tumor necrosis factor-(TNF), C-reactive protein (CRP) and blood cell counts in persons with spinal cord injury (SCI).Setting:The 2009 Mei-shin League of Wheelchair Basketball Games held at Wakayama, Japan.Participants:Five wheelchair basketball players with SCI voluntarily participated in this study.Interventions:Blood samples were taken approximately 1 h before the player warm-up for the game and immediately after the game.Main outcome measures:IL-6, TNF CRP and blood cell count were measured.Results:Plasma IL-6 level and number of monocytes were significantly increased after the game, compared with pre-game measurements (P<0.05). No changes were observed in other measurements. There was a significant relationship between increased IL-6 levels and accumulated play duration.Conclusion:The lack of change in TNF and CRP levels suggested that the exercise-induced rise in IL-6 was not related to exercise-induced inflammatory response. Furthermore, the associated increase in the number of monocytes did not correlate with exercise-induced IL-6 changes, negating monocytes as the source of IL-6. © 2013 International Spinal Cord Society All rights reserved.