Influence of pH on the efficacy of pilocarpine

Abstract

Pilocarpine 4%Y solutions at pH 4-1 and 5-8 were compared in a double-blind clinical trial on 24 eyes of patients with primary open-angle glaucoma. Each drug was used over a period of 1 week. No significant difference in the lowering of intraocular pressure was found, and the near-neutral solution of pilocarpine was found to be equally stable when compared to the acid solution over a 6-month period.