More than one ring to bind them all: Recent insights into the structure of the axon

Abstract

This brief review outlines recent developments in the understanding of the ultrastructural organization of the axonal and growth cone actin filament cytoskeleton. A novel form of structural organization has arisen as a regulator of the actin cytoskeleton: ring-like structures. Rings may represent a conserved functional theme exhibited by diverse molecular systems and have implications for the understanding of the axon in development, maturity, and disease. © 2013 Wiley Periodicals, Inc.