Long-lasting LTP requires neither repeated trains for its induction nor protein synthesis for its development

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Abstract

Current thinking about LTP triggered in the area CA1 of hippocampal slices is ruled by two "dogmas": (1) A single train of high-frequency stimulation is sufficient to trigger short-lasting LTP (1 - 3 h), whereas multiple trains are required to induce long-lasting LTP (L-LTP, more than 4 h). (2) The development of the late phase of L-LTP requires the synthesis of new proteins. In this study, we found that a single high-frequency train could trigger an LTP lasting more than 8 h that was not affected by either anisomycin or cycloheximide (two inhibitors of protein synthesis). We ascertained that the induction of this L-LTP made use of the same mechanisms as those usually reported to be involved in LTP induction: it was dependent on NMDA receptors and on the activation of two "core" kinases, CaMKII and PI3K. These findings call into question the two "dogmas" about LTP. © 2012 Villers et al.

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Villers, A., Godaux, E., & Ris, L. (2012). Long-lasting LTP requires neither repeated trains for its induction nor protein synthesis for its development. PLoS ONE, 7(7). https://doi.org/10.1371/journal.pone.0040823

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