Application of response surface methodology to optimize the extraction of acetylcholinesterase inhibitors from Rhodiola sachalinensis

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Abstract

Response surface methodology (RSM) was utilized to optimize extraction conditions for the acetylcholinesterase inhibitor from Rhodiola sachalinensis. Optimized values for AChE inhibition and extraction yield were 19.41 and 13.35%, respectively, and these were in good agreement with the experimental values from validation, suggesting that RSM is a useful tool.

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Kim, C. R., Kim, J. K., Shin, E. C., Choi, S. J., Kwon, Y. K., Kim, Y. J., … Shin, D. H. (2014). Application of response surface methodology to optimize the extraction of acetylcholinesterase inhibitors from Rhodiola sachalinensis. Journal of the Korean Society for Applied Biological Chemistry, 57(6), 807–811. https://doi.org/10.1007/s13765-014-4293-8

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