Ribosomal vaccines. II. Specificity of the immune response to ribosomal ribonucleic acid and protein isolated from Salmonella typhimurium

Abstract

Ribosomal proteins isolated from S. typhimurium were effective in inducing immunity in mice. This immunity was specific since animals immunized with ribosomal proteins from S. typhimurium were not protected against challenge with S. cholerae suis or S. enteritidis. Immunity was evident as early as 5 days after immunization. Ribosomal RNA failed to provide any effective immunity in mice. Polyinosinic acid: polycytidylic acid (poly I:C) induced a rapid, short lived immunity to all three Salmonella species. In contrast, ribosomal RNA failed to elicit any rapid nonspecific response to infection.