Motor nerve conduction study in patients on diphenylhydantoin therapy

Abstract

Mean motor conduction velocity of posterior tibial nerves was significantly reduced in epileptic patients treated with diphenylhydantoin for more than 10 years or in patients with serum diphenylhydantoin level above 20 ,ug/ml. Subnormal serum folate was not responsible for this reduction and clinical peripheral neuropathy was infrequent.