Gamma glutamyl transferase and lactate dehydrogenase as biochemical markers of severity of preeclampsia among Sudanese pregnant women

Abstract

Background: Preeclampsia is a disorder of widespread vascular endothelial malfunction and vasospasm that occurs after 20 weeks' gestation and can present as late as 4-6 weeks post-partum. Pre-eclampsia is a syndrome with multiple aetiologies which has made it difficult to develop adequate screening tests and treatments. Objective of this study to assess the level of gamma glutamyl transferase and lactate dehydrogenase as biochemical markers of severity of preeclampsia in Sudanese pregnant women.Methods: This is a case control hospitalize base study. The study was conducted in preeclamptic pregnant women in Omdurman maternity hospital and medical military hospital in Khartoum state. In this study glutamyl transferase and lactate de-hydrogenase was estimation in 100 Sudanese pregnant women by spectrophotometer method, 50 of them were diagnosed with preeclampsia 27 from this is severe preeclampsia and 23 is mild preeclampsia was matched in aged. Serum samples of all the cases were assayed for GGT and LDH. The data was recorded and analyzed using statistical package for social sciences (SPS –version 16) on programmed computer. The mean standard deviations of variable were calculated for both the test group and the control group and P value for comparison was obtained.Results: The mean values of plasma gamma glutamyl transferase in mild and severe preeclamptic pregnant women were insignificant difference when compared to control P value (0.346 - 0.089) respectively. The mean values of plasma lactate dehydrogenase in mild and severe preeclamptic pregnant women were significant increase when compared to control P value (0.008 - 0.001) respectively.Conclusions: The levels of LDH is raised in Sudanese pregnant women with hypertensive also can be useful biochemical marker that reflects the severity of and the occurrence of complications of pre-eclampsia. GGT levels were normal in Sudanese pregnant women with hypertensive preeclampsia.