Asymmetric synthesis of α-hydroxy carboxylic acids: direct oxidation of chiral amide enolates using 2-sulfonyloxaziridines

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Abstract

The direct oxidation of chiral amide enolates to optically active mandelic acid using 2-sulfonyloxaziridine 1 is described. The diastereoselectivity is counterion dependent. © 1985.

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Davis, F. A., & Vishwakarma, L. C. (1985). Asymmetric synthesis of α-hydroxy carboxylic acids: direct oxidation of chiral amide enolates using 2-sulfonyloxaziridines. Tetrahedron Letters, 26(30), 3539–3542. https://doi.org/10.1016/S0040-4039(00)89185-6

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