Investigation of carbohydrate recognition via computer simulation

14Citations
Citations of this article
28Readers
Mendeley users who have this article in their library.

Abstract

Carbohydrate recognition by proteins, such as lectins and other (bio)molecules, can be essential for many biological functions. Recently, interest has arisen due to potential protein and drug design and future bioengineering applications. A quantitative measurement of carbohydrate-protein interaction is thus important for the full characterization of sugar recognition. We focus on the aspect of utilizing computer simulations and biophysical models to evaluate the strength and specificity of carbohydrate recognition in this review. With increasing computational resources, better algorithms and refined modeling parameters, using state-of-the-art supercomputers to calculate the strength of the interaction between molecules has become increasingly mainstream. We review the current state of this technique and its successful applications for studying protein-sugar interactions in recent years.

Cite

CITATION STYLE

APA

Johnson, Q. R., Lindsay, R. J., Petridis, L., & Shen, T. (2015, May 1). Investigation of carbohydrate recognition via computer simulation. Molecules. MDPI AG. https://doi.org/10.3390/molecules20057700

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free