A clinical study on cefroxadine (CGP-9000) in surgical field

Abstract

Cefroxadine (CGP-9000, CXD), a new orally antibiotic derived from cephalosporin, has a broad spectrum and a bacteriocidal action. The authors investigated serum levels, urinary excretion, clinically effectiveness and untoward side effects of the agent. The result obtained are summarized as follows : 1. Following an oral administration of 250 mg CXD in 4 healthy adult volunteers, the mean serum levels showed a peak of 10.7 μg/ml 2 hours after administration, with 195.2 mg(78.1%) urinary excretion within 6 hours. 2. CXD was given on 51 patients with infections in the field of surgery, and the result was excellent in 28 cases, good 19, poor 4, the effectiveness rate accounting for 92.2%. 3. Side effects were not observed in all cases among 51 patients in CXD trial. © 1980, Japanese Society of Chemotherapy. All rights reserved.