Background: The aim of the current study was to improve our understanding of the origins and transmission of Mycobacterium africanum (MAF) in Norway. Methods: Whole-genome sequences (WGS) were generated for all (n = 29) available clinical isolates received at the Norwegian National Reference Laboratory for Mycobacteria (NRL) and identified as MAF in Norway, in the period 2010–2020. Phylogenetic analyses were performed. Results: The analyses indicated several imports of MAF lineage 6 from both East and West African countries, whereas MAF lineage 5 was restricted to patients with West African connections. We also find evidence for transmission of MAF in Norway. Finally, our analyses revealed that a group of isolates from patients originating in South Asia, identified as MAF by means of a commercial line-probe assay, in fact belonged to Mycobacterium orygis. Conclusions: Most MAF cases in Norway are the result of import, but transmission is occurring within Norway.
CITATION STYLE
Eldholm, V., Rønning, J. O., Mengshoel, A. T., & Arnesen, T. (2021). Import and transmission of Mycobacterium orygis and Mycobacterium africanum, Norway. BMC Infectious Diseases, 21(1). https://doi.org/10.1186/s12879-021-06269-3
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