The Sperm Centrosome: Its Role and Significance in Nature and Human Assisted Reproduction

Abstract

In humans and other non-rodent mammalian species, the sperm's centriole-centrosome complex is an essential component for successful fertilization and serves as template for all centrioles during subsequent cell divisions, embryo development, divisions of most adult somatic cells, as well as in primary cilia formation and functions. Dysfunctions of this complex can be causes for infertility, developmental disorders, and play a role in various adulthood diseases. While assisted reproductive technology (ART) has been able to overcome sperm motility dysfunctions by employing intracytoplasmic sperm injection (ICSI), we currently do not yet have therapies to overcome dysfunctions of the centriole-centrosome complex although several lines of investigations have addressed the causes for centriole-centrosome dysfunctions and implications for sperm aster formation and union of the parental genomes. The present review highlights the importance of the centriole-centrosome complex and its significance for fertilization and embryo development.