DOT cells for colorectal cancer immunotherapy

Abstract

Delta One T (DOT) cells are primarily Vδ1+ γδ T cells with strong cytotoxic activity, now in clinical studies for the treatment of leukemias but not yet evaluated in solid cancers. Adoptive transfer of DOT cells combined with butyrate or checkpoint inhibitors is now shown to be an effective therapy for colorectal cancer in preclinical models.