Impact of Body Mass Index and Comorbidities on Health-Related Quality of Life and Work Productivity in People With Overweight or Obesity: A Survey-Based Study in the United Kingdom

Abstract

Background: The prevalence and socioeconomic impact of obesity are increasing in the United Kingdom; however, the effects of body mass index (BMI) and comorbidities on health-related quality of life (HRQoL) and work productivity in people living with overweight or obesity (PLwO) have not been fully described. Objective: To assess self-reported HRQoL and work productivity in PLwO in the United Kingdom, grouped by BMI and presence of cardiovascular and/or metabolic (CVM) comorbidities. Methods: Data used were from the Adelphi Obesity Disease Specific Programme™, a real-world cross-sectional survey (October 2023–April 2024). Physicians reported demographic and clinical characteristics for PLwO on a weight management program who were ≥18 years old and had current or previous BMI ≥30 kg/m2, or ≥27 kg/m2 with ≥1 weight-related comorbidity. The same PLwO completed the 36-item Short-Form Health Survey version 2 (SF-36v2) and Work Productivity and Activity Impairment: Specific Health Problem (WPAI:SHP) questionnaire. Results: Physicians provided data for 904 PLwO, of whom 119 completed the survey questionnaires. Mean age for PLwO was 51.7 years, 54% were women, the majority were White (69%), and 70% had ≥1 CVM comorbidity. SF-36v2 physical functioning scores were lower with higher BMI (P