Responsiveness of urinary and plasma alkylresorcinol metabolites to rye intake in finnish women

Abstract

Alkylresorcinols [ARs] have been proposed for use as biomarkers of wholegrain intake. The aim here was to examine the responsiveness of AR metabolites to rye intake. Sixty women were divided into three groups according to their rye consumption. We observed significant differences between groups in plasma 3-[3,5-dihydroxyphenyl]-1-propanoic acid [DHPPA] and in urinary DHPPA and 3,5-dihydroxybenzoic acid [DHBA]. In addition, these AR metabolites increased proportionally to rye fiber intake. We conclude that these ARs metabolites are accurate and useful biomarkers of rye fiber intake. Further studies are needed to confirm our results in larger and different populations. © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.