Synthesis, Characterization and Preliminary Antimicrobial and Antiinflammatory Evaluation of New Ibuprofen Hydrazide Derivatives

Abstract

Non-steroidal anti-inflammatory medicines (NSAIDs) are medicines that are distributed widely across the world due to their ability to reduce pain and inflammation. In order to boost the drug’s efficacy and reduce its harmful side effect like GIT ulcers and bleeding, a newly synthesized series of25-(1-(4-isobutylphenyl) ethyl)-1,3,4-oxadiazole-2-thiol derivatives compounds (C, C 1-3) were prepared from the reaction of ibuprofen hydrazide with carbon disulfide followed by reaction with various Aryl/ alkyl halide. All target compounds were tested for antimicrobial efficacy against various strains of bacteria (G+ve, S. pyrogenes and S. aureus) and (G-ve, E. coli and1Klebsiella pneumoniae). Additionally, fungus species (Candida albicans). Compound C showed good antimicrobial activity for both bacterial strains. At the same time, Compound C1 have the best ant-bacterial activity compared with other synthesized compounds for1 both (G+ve), and (G-ve) bacteria, and compound C3 was the most affected one as antifungal. The compound C2 was with lowest antimicrobial activity. All of the produced compounds were examined for their anti-inflammatory activity using (egg-white generate edema) and the compounds (C, C1, C3) showed good efficacy when compared to ibuprofen (stander) FTIR and1H-NMR spectroscopy were used to analyze all of the final products.