The squalestatins, novel inhibitors of squalene synthase produced by a species of phoma: II. structure elucidation

Abstract

Three novel fungal metabolites 1~3 isolated from cultures of a Phoma sp. C2932, are potent and selective inhibitors of squalene synthase. Their structures have been determined by a combination of spectroscopic, X-ray crystallographic and chemical methods; these natural products incorporate the highly functionalised bicyclic core, [lS-(lα,3α,4β,5α,6α,7β)]-4,6,7-trihydroxy-2,8-dioxabicyclo-[3.2. l]octane-3,4,5-tricarboxylic acid. © 1992, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.