Reversible Acute Kidney Injury Associated with Sildenafil Overdose

Abstract

Sildenafil is a phosphodiesterase type 5 inhibitor that is approved to treat erectile dysfunction and pulmonary hypertension. Generally, sildenafil is safe, with mild side effects. Here, we report a case of acute kidney injury caused by a sildenafil overdose. A 67-year-old man took 400 mg of sildenafil for erectile dysfunction. The patient was found to have acute kidney injury from acute tubular necrosis during hospitalization with a peak serum creatinine of 5.07 mg/dL though his renal function recovered with supportive care.