Red hair, MC1R variants, and risk for Parkinson's disease – a meta-analysis

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Abstract

Several studies have been conducted with mixed results since our initial report of increased Parkinson's disease risk in individuals with red hair and/or red hair-associated p.R151C variant of the MC1R gene, both of which confer high melanoma risk. We performed a meta-analysis of six publications on red hair, MC1R, and Parkinson's disease. We found that red hair (pooled odds ratios = 1.68, 95% confidence intervals: 1.07, 2.64) and p.R151C (pooled odds ratios = 1.10, 95% confidence intervals: 1.00, 1.21), but not p.R160W, were associated with greater risk for Parkinson's disease. Our results support potential roles of pigmentation and its key regulator MC1R in the pathogenesis of Parkinson's disease.

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Chen, X., Feng, D., Schwarzschild, M. A., & Gao, X. (2017). Red hair, MC1R variants, and risk for Parkinson’s disease – a meta-analysis. Annals of Clinical and Translational Neurology, 4(3), 212–216. https://doi.org/10.1002/acn3.381

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