Chemical constituents from the ethyl acetate extract of salvia hydrangea

Abstract

One new triterpenoid, 3β-O-(2-hydroxybenzoyl)-ursolic acid (1), and 11 known compounds, including 5 triterpenoids, 2 steroidal compounds, and 4 phenolic compounds were isolated from the ethyl acetate extract of the aerial parts of Salvia hydrangea. Their structures were elucidated based on the extensive spectroscopic data, including 1-dimensional and 2-dimen-sional nuclear magnetic resonance spectra, high resolution-electrospray ionization mass spectrometry, and by comparison with literature data. The antiprotozoal activity of compound 1 was evaluated against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, Plasmodium falciparum and showed no activities against all parasite tested.