Tumor-infiltrating regulatory T cells (Tregs) promote immune evasion and are associated with poor disease outcome in patients affected by various malignancies. We have recently demonstrated that several, inherited single nucleotide polymorphisms affecting Treg-related genes influence the survival of ovarian cancer patients, providing novel insights into possible mechanisms of immune escape.
CITATION STYLE
DeRycke, M. S., Charbonneau, B., Preston, C. C., Kalli, K. R., Knutson, K. L., Rider, D. N., & Goode, E. L. (2013). Toward understanding the genetics of regulatory T cells in ovarian cancer. OncoImmunology, 2(6), e24535. https://doi.org/10.4161/onci.24535
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