Toward understanding the genetics of regulatory T cells in ovarian cancer

  • DeRycke M
  • Charbonneau B
  • Preston C
  • et al.
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Abstract

Tumor-infiltrating regulatory T cells (Tregs) promote immune evasion and are associated with poor disease outcome in patients affected by various malignancies. We have recently demonstrated that several, inherited single nucleotide polymorphisms affecting Treg-related genes influence the survival of ovarian cancer patients, providing novel insights into possible mechanisms of immune escape.

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DeRycke, M. S., Charbonneau, B., Preston, C. C., Kalli, K. R., Knutson, K. L., Rider, D. N., & Goode, E. L. (2013). Toward understanding the genetics of regulatory T cells in ovarian cancer. OncoImmunology, 2(6), e24535. https://doi.org/10.4161/onci.24535

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