A new sesquiterpene with an α-methylene-γ-lactone moiety, artabolide (1), and three known derivatives 2-4 were isolated from Artemisia absinthium. The structure of 1 was elucidated by 1D and 2D NMR analyses, and the absolute configuration was determined using the modified Mosher's method and X-ray crystal structural analysis. Approximately 2.5 μg/plant treatment of artabolide (1) exhibited ca. 50% inhibition of polar auxin transport in radish hypocotyls, while 2-4 showed no significant inhibitory activity. Therefore, these results support the importance of the α-methylene-γ-lactone moiety for the inhibition of polar auxin transport. © 2013 Elsevier Ltd. All rights reserved.
CITATION STYLE
Arai, T., Toda, Y., Kato, K., Miyamoto, K., Hasegawa, T., Yamada, K., … Shigemori, H. (2013). Artabolide, a novel polar auxin transport inhibitor isolated from Artemisia absinthium. Tetrahedron, 69(34), 7001–7005. https://doi.org/10.1016/j.tet.2013.06.052
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