Integrating high-throughput screening and sequencing for monoclonal antibody discovery and engineering

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Abstract

Monoclonal antibody discovery and engineering is a field that has traditionally been dominated by high-throughput screening platforms (e.g. hybridomas and surface display). In recent years the emergence of high-throughput sequencing has made it possible to obtain large-scale information on antibody repertoire diversity. Additionally, it has now become more routine to perform high-throughput sequencing on antibody repertoires to also directly discover antibodies. In this review, we provide an overview of the progress in this field to date and show how high-throughput screening and sequencing are converging to deliver powerful new workflows for monoclonal antibody discovery and engineering.

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Parola, C., Neumeier, D., & Reddy, S. T. (2018, January 1). Integrating high-throughput screening and sequencing for monoclonal antibody discovery and engineering. Immunology. Blackwell Publishing Ltd. https://doi.org/10.1111/imm.12838

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