Correlation between Inflammatory Markers of Platelet Index and Vitamin D with Body Mass Index

Abstract

Weight loss remains a worldwide health problem and a risk factor for chronic disease. Decreased serum vitamin D levels in excessive body weight lead to low-grade inflammation. This study aimed to determine the relationship between the platelet index such as Mean Platelet Volume (MPV), Platelet Large Cell Ratio (P-LCR) as an inflammatory marker, and vitamin D as an anti-inflammatory marker with body mass index (BMI). This study was a cross-sectional study of 78 female patients at the Diponegoro National Hospital with an overweight (BMI> 23) state from July to September 2020. Data analysis was performed using Pearson and Spearman tests and p <0.05 was significant. Of the 78 research samples, there was a significant relationship between BMI and MPV (r=0.404; p=0.000); P-LCR (r=0.425; p=0.000) and 25(OH) D (r=-0.231; p=0.04). Low vitamin D levels in obesity and low-grade inflammation increase proinflammatory cytokines. Increased leptin levels in obesity contribute to platelet hyperreactivity. Increased platelet activity compensates for the platelets so that the MPV and P-CLR values increase. This study found a moderate significant positive relationship between MPV, P-CLR, and BMI but a weak significant negative relationship between 25(OH) D and BMI.