Determination of fluoxetine and norfluoxetine in plasma by gas chromatography with electron-capture detection

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Abstract

This gas-chromatographic method for assay of fluoxetine and norfluoxetine in human plasma involves extraction of the drugs and use of a 63Ni electron-capture detector. The linear range of detection is 25 to 800 μg/L for each drug. Overall precision (CV) in the concentration range of 10 to 100 μg/L for both drugs was approximately 10%. Accuracy (relative error) in the same concentration range was approximately +10%. None of the commonly prescribed antidepressants or tranquilizers that we tested interfere with the assay.

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Nash, J. F., Bopp, R. J., Carmichael, R. H., Farid, K. Z., & Lemberger, L. (1982). Determination of fluoxetine and norfluoxetine in plasma by gas chromatography with electron-capture detection. Clinical Chemistry, 28(10), 2100–2102. https://doi.org/10.1093/clinchem/28.10.2100

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