Cascade reactions using LiAlH4 and Grignard reagents in the presence of water

Abstract

(Figure Presented) Divided we stand, together we fall: Incompatible reagents, such as water and LiAlH4, Grignard, or cuprate reagents, can be site-isolated on either side of a polydimethylsiloxane (PDMS) thimble (see scheme; SDS = sodium docecyl sulfate) for cascade reactions. The hydrophobic nature of the PDMS membrane prohibits polar molecules, such as water, from diffusing across the membrane. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.