Facile synthesis of substituted arylthioureas in the presence of sodium hydride

Abstract

A series of 11 1,1-dimethyl-3-aryl-thioureas were synthesised in good yields (70-92%) by reacting arylamines with S-aryl-N,Ndimethylthiocarbamate in DMSO in the presence of NaH at 90 °C. It is noteworthy that this method can also be used for arylamines containing a halogen atom at the ortho position.