Abstract
A significantly simpler analog of the natural product migrastatin, termed migrastatin ether (ME), has been prepared and evaluated. Both in vivo and in vitro studies indicate that ME exhibits a concentrationdependent inhibitory effect on migration of breast cancer cells. © 2010 American Chemi cal Society.
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CITATION STYLE
Oskarsson, T., Nagorny, P., Krauss, I. J., Perez, L., Mandal, M., Yang, G., … Danishefsky, S. J. (2010). Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: In vivo and mechanistic studies on the migrastatin core ether analog. Journal of the American Chemical Society, 132(9), 3224–3228. https://doi.org/10.1021/ja9101503
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