CBX7 is involved in the progression of cervical cancer through the ITGβ3/TGFβ1/AKT pathway

Abstract

The chromobox protein homolog 7 (CBX7) serves a tumor‑suppressive role in human malignant neoplasias. The downregulation of CBX7 is associated with the poor prognosis and aggressiveness of various human cancers. However, the biological functions and underlying mechanisms of CBX7 in cervical cancer remain unclear. The present study investigated the role and mechanism of CBX7 in cervical cancer. Lentivirus and siRNA were used to construct cervical cancer cells with stable CBX7 knockdown and SiHa xenograft models. The