Rubinstein-Taybi syndrome

Abstract

This is a rare cause of mental handicap. Case finding studies in several English speaking countries have found about one case per 300 institutionalised subjects. Assuming that at that time about 1 per 1000 of the general population required institutionalisation the population frequency would be about 1 in 300,000. Sex ratio, parental ages, pregnancy history, and birth weights have been unremarkable in all studies. Cases have been reported from all racial groups.