Synthesis and Antimicrobial Studies of Tridentate Schiff Base Ligands with Pyrazolone Moiety and Their Metal Complexes

Abstract

Synthesis, characterization, and antimicrobial activity of tridentate Schiffbase ligands containing pyrazolone moiety ( 3a and 3b ) and their transition metal complexes of VO(II), Cu(II), Fe(III), and Co(II) 4a – h have been investigated. The complexes show enhanced antibacterial activity against S. aureus, E. coli, and S. typhi and antifungal activity against C. albicans, Rhizopus sp., and A. niger compared to the ligands.